Therapeutic Specialties

AISER specializes in key therapeutic areas. This focus allows us to provide scientific expertise, operational excellence, and close alignment with our clients' goals.

Ramaz Miraishvili Research Fellow

Elevated free plasma DNA is a reliable indicator of recurrent esophageal cancer, more so than carcinoembryonic antigen (CEA), and is able to detect recurrent disease in most patients before clinical evidence emerges. These findings come from a study by researchers at the University of Southern California, published in the July issue of the Journal of the American College of Surgeons.

A new review by three renowned experts in cardiology suggests that efforts to treat elevated cholesterol levels are not exploiting the full potential of cholesterol-lowering strategies, and current approaches to treatment are simply doing "too little, too late. [1]" The evidence, say these experts, is strong enough to support even more aggressive use of lipid-lowering therapies and to intervene at earlier stages in the development of atherosclerosis.

Polyalkylimide implants (PAI) used as dermal fillers can infrequently result in delayed and recurrent chronic inflammatory and granulomatous reactions, according to the results of a study published in the May issue of the Archives of Dermatology.

Results of a randomized trial show that tibolone (Livial, Organon), approved for treatment of menopausal symptoms, has positive effects on fracture, breast cancer, and possibly colon cancer in women with osteoporosis over the age of 60 years but more than doubled the risk for stroke.

Almost All Articles On Cancer Prognostic Markers Report Statistically Significant Results: Commentary from F1000

Kyzas PA, Denaxa-Kyza D, Ioannidis JP

Eur J Cancer 2007 Nov 43(17):2559-79

Commentary from Faculty Member Willi Sauerbrei

This is a landmark review illustrating the severity of reporting bias in prognostic marker research. The article impressively illustrates one of the most severe weaknesses of cancer prognostic marker research. Altogether more than 1900 articles were assessed, of which only 26 articles were fully 'negative'.